Article
Physiological restraint of Bak by Bcl-xL is essential for cell survival.
Genes & development - 15 May 2016
Lee Erinna F, Grabow Stephanie, Chappaz Stephane, Dewson Grant, Hockings Colin, Kluck Ruth M, Debrincat Marlyse A, Gray Daniel H, Witkowski Matthew T, Evangelista Marco, Pettikiriarachchi Anne, Bouillet Philippe, Lane Rachael M, Czabotar Peter E, Colman Peter M, Smith Brian J, Kile Benjamin T, Fairlie W Douglas
Abstract excerpt
Due to the myriad interactions between prosurvival and proapoptotic members of the Bcl-2 family of proteins, establishing the mechanisms that regulate the intrinsic apoptotic pathway has proven challenging. Mechanistic insights have primarily been gleaned from in vitro studies because genetic approaches in mammals that produce unambiguous data are difficult to design. Here we describe a mutation in mouse and...
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