Pro-apoptotic activity of transiently expressed BCL-2 occurs independent of BAX and BAK.

doi:10.1002/jcb.10573

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Article

Pro-apoptotic activity of transiently expressed BCL-2 occurs independent of BAX and BAK.

Journal of cellular biochemistry - 15 Aug 2003

Subramanian T, Chinnadurai G

Abstract excerpt

BCL-2 suppresses apoptosis induced by a wide variety of stimuli in multiple cell types. Most of the in vitro studies that have examined the activity of BCL-2 have employed stable cell lines that ectopically express BCL-2. We have reported that BCL-2 is expressed at high levels in the absence of the 5'- and 3'-UTRs of the Bcl-2 gene and transient high level of expression results in potent cell death (Uhlmann et...

Topics

Apoptosis
Caspases
Cell Line, Tumor
Enzyme Activation
Genes, bcl-2
Humans
Immunoblotting
Membrane Proteins
Mutation
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
Untranslated Regions
bcl-2 Homologous Antagonist-Killer Protein
bcl-2-Associated X Protein

Source

Open in PubMed

Identifiers

PMID: 12898509
DOI: 10.1002/jcb.10573

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