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Article

Distinct domains of Bcl-XL are involved in Bax and Bad antagonism and in apoptosis inhibition.

Experimental cell research - 1 Oct 2005

Zhou Hui, Hou Qi, Chai Yunfei, Hsu Yi-Te

Abstract excerpt

Pro-survival factor Bcl-X(L) can antagonize the pro-apoptotic functions of Bax and Bad via two distinct mechanisms. It can block Bax-mediated cell death by preventing Bax translocation from the cytosol to mitochondria. On the other hand, Bcl-X(L) can neutralize Bad by sequestering it to mitochondria. In order to map the domains of Bcl-X(L) involved in inhibiting Bax and Bad, we have carried out mutational...

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Identifiers

PMID: 16061221
DOI: 10.1016/j.yexcr.2005.06.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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