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p53-Dependent p21 mRNA Elongation Is Impaired when DNA Replication Is Stalled

12 Dec 2006

Abstract excerpt

We have previously reported that when DNA replication is blocked in some human cell lines, p53 is impaired in its ability to induce a subset of its key target genes, including p21(WAF1/CIP1). Here, we investigated the reason for this impairment by comparing the effects of two agents, hydroxyurea (HU), which arrests cells in early S phase and impairs induction of p21, and daunorubicin, which causes a G(2) block...

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PMID: 17158927
DOI: 10.1128/mcb.01520-06

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