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Article

Tetrahymena POT1a regulates telomere length and prevents activation of a cell cycle checkpoint.

Molecular and cellular biology - 1 Mar 2007

Jacob Naduparambil K, Lescasse Rachel, Linger Benjamin R, Price Carolyn M

Abstract excerpt

The POT1/TEBP telomere proteins are a group of single-stranded DNA (ssDNA)-binding proteins that have long been assumed to protect the G overhang on the telomeric 3' strand. We have found that the Tetrahymena thermophila genome contains two POT1 gene homologs, POT1a and POT1b. The POT1a gene is essential, but POT1b is not. We have generated a conditional POT1a cell line and shown that POT1a depletion results in a...

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Source

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Identifiers

PMID: 17158924
DOI: 10.1128/MCB.01975-06
PMCID: PMC1820449

Genes

ATM
ATR
POT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tetrahymena POT1a regulates telomere length and prevents activation of a cell cycle checkpoint.PMID 17158924Read ↗

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