Article
Hyperaccurate and error-prone ribosomes exploit distinct mechanisms during tRNA selection.
Molecular cell - 9 Jul 2010
Zaher Hani S, Green Rachel
Abstract excerpt
Escherichia coli strains displaying hyperaccurate (restrictive) and ribosomal ambiguity (ram) phenotypes have long been associated with alterations in rpsL and rpsD/rpsE, respectively. Crystallographic evidence shows the ribosomal proteins S12 and S4/S5 (corresponding to these genes) to be located in separate regions of the small ribosomal subunit that are important for domain closure thought to take place during...
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