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Article

Pharmacogenetics of Dopamine β-Hydroxylase in cocaine dependence therapy with doxazosin.

Addiction biology - 1 May 2019

Zhang Xuefeng, Nielsen David A, Domingo Coreen B, Shorter Daryl I, Nielsen Ellen M, Kosten Thomas R

Abstract excerpt

The α1 -adrenergic antagonist, doxazosin, has improved cocaine use disorder (CUD) presumably by blocking norepinephrine (NE) stimulation and reward from cocaine-induced NE increases. If the NE levels for release were lower, then doxazosin might more readily block this NE stimulation and be more effective. The NE available for release can be lower through a genetic polymorphism in dopamine β-hydroxylase (DBH)...

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Share to Cocaine-Related Disorders
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29498170
DOI: 10.1111/adb.12611
PMCID: PMC6119656

Genes

DBH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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