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Article

Immunogenetic factors determining the evolution of T-cell large granular lymphocyte leukaemia and associated cytopenias.

British journal of haematology - 1 Jan 2007

Nearman Zachary P, Wlodarski Marcin, Jankowska Anna M, Howe Evan, Narvaez Yadira, Ball Edward, Maciejewski Jaroslaw P

Abstract excerpt

T-cell large granular lymphocyte leukaemia (T-LGL) is a chronic clonal proliferation of cytotoxic T lymphocytes (CTL). T-LGL presents with cytopenias, often accompanied by autoimmune diseases, suggesting clonal transformation arising from an initially polyclonal immune response. Various immunogen...

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Share to Antigens, Differentiation
Share to CTLA-4 Antigen
Share to Cytotoxicity, Immunologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, T-Cell

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Share to Receptors, Cytokine

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Source

Identifiers

PMID: 17156396
DOI: 10.1111/j.1365-2141.2006.06429.x

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17156396-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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