Article
Current concepts: large granular lymphocyte leukemia.
Blood reviews - 1 Dec 1999
Lamy T, Loughran T P
Abstract excerpt
Clonal diseases of large granular lymphocyte (LGL) disorders can arise from a CD3+ T-cell lineage or from a CD3- NK-cell lineage. CD3+ LGL leukemia is the most frequent form of LGL leukemia. T-LGL leukemia usually affects elderly people. Approximately 60% of patients are symptomatic; recurrent infections secondary to chonic neutropenia, anemia, and rheumatoid arthrititis are the main clinical manifestations. The...
Topics
- Autoimmune Diseases
- CD3 Complex
- Cell Lineage
- Female
- Humans
- Killer Cells, Natural
- Leukemia, Lymphoid
- Leukemia, T-Cell
- Male
- Phenotype
