Insights Into Genetic Landscape of Large Granular Lymphocyte Leukemia

doi:10.3389/fonc.2020.00152

Article

Insights Into Genetic Landscape of Large Granular Lymphocyte Leukemia

18 Feb 2020

Abstract excerpt

Large granular lymphocyte leukemia (LGLL) is a chronic proliferation of clonal cytotoxic lymphocytes, usually presenting with cytopenias and yet lacking a specific therapy. The disease is heterogeneous, including different subsets of patients distinguished by LGL immunophenotype (CD8+ Tαβ, CD4+ Tαβ, Tγδ, NK) and disease clinical course (indolent/symptomatic/aggressive). Even if the etiology of LGLL remains...

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