Large granular lymphocyte leukemia: a clonal disorder with autoimmune manifestations.

doi:10.1182/hematology.2024000539

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Article

Large granular lymphocyte leukemia: a clonal disorder with autoimmune manifestations.

Hematology. American Society of Hematology. Education Program - 6 Dec 2024

Marchand Tony, Pastoret Cédric, Moignet Aline, Roussel Mikael, Lamy Thierry

Abstract excerpt

Large granular lymphocyte (LGL) leukemia is a rare lymphoproliferative disorder characterized by an expansion of clonal T or natural killer lymphocytes. Neutropenia-related infections and anemia represent the main manifestations. LGL leukemia is frequently associated with autoimmune disorders such as rheumatoid arthritis, Sjögren's syndrome, autoimmune endocrinopathies, vasculitis, or autoimmune cytopenia. Recent...

Topics

Humans
Leukemia, Large Granular Lymphocytic
Autoimmune Diseases
STAT3 Transcription Factor
Mutation
Signal Transduction
Autoimmunity
Immunosuppressive Agents

Source

Open in PubMed Open full text

Identifiers

PMID: 39644019
DOI: 10.1182/hematology.2024000539
PMCID: PMC11665628

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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