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Article

Phenotypic differences between healthy effector CTL and leukemic LGL cells support the notion of antigen-triggered clonal transformation in T-LGL leukemia.

Journal of leukocyte biology - 1 Mar 2008

Wlodarski Marcin W, Nearman Zachary, Jankowska Anna, Babel Nina, Powers Jennifer, Leahy Patrick, Volk Hans-Dieter, Maciejewski Jaroslaw P

Abstract excerpt

T cell large granular lymphocyte leukemia (T-LGL) is a chronic clonal lymphoproliferation of CTL. In many ways, T-LGL clones resemble terminal effector CTL, including down-modulation of CD28 and overexpression of perforin, granzymes, and CD57. We studied the transcriptome of T-LGL clones and compared it with healthy CD8+CD57+ effector cells as well as CD8+CD57- populations. T-LGL clones were sorted based on their...

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Share to DNA, Neoplasm
Share to Flow Cytometry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Leukemia, Large Granular Lymphocytic

Share to Neoplasm Proteins

Share to Oligonucleotide Array Sequence Analysis

Share to Polymerase Chain Reaction

Share to T-Lymphocytes, Cytotoxic

Source

Open in PubMed Open full text

Identifiers

PMID: 18086899
DOI: 10.1189/jlb.0107073
PMCID: PMC2629660

Genes

CCR2
CXCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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