Article
Familial CD3+ T large granular lymphocyte leukemia: evidence that genetic predisposition and antigen selection promote clonal cytotoxic T-cell responses.
Leukemia & lymphoma - 1 Aug 2014
Stalika Evangelia, Papalexandri Apostolia, Iskas Michalis, Stavroyianni Niki, Kanellis George, Kotta Konstantina, Pontikoglou Charalambos, Siorenta Alexandra, Anagnostopoulos Achilles, Papadaki Helen, Papadaki Theodora, Stamatopoulos Kostas
Abstract excerpt
CD3+ T-large granular lymphocyte (T-LGL) proliferations often present with cytopenias and splenomegaly and are linked to autoimmunity, especially rheumatoid arthritis and Felty's syndrome. We report here the intra-family occurrence of T-LGL leukemia in a father and son, both presenting with cytopenias and splenomegaly. Both patients carried the HLA-DRB1*04 allele, strongly associated with rheumatoid arthritis and...
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