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Diagnosis and Management of Large Granular Lymphocytic Leukaemia and Its Differentiation From T Cell Clones of Uncertain Significance

1 Jun 2025

Abstract excerpt

Large granular lymphocytic leukemia (LGLL) is a chronic clonal T- or NK-cell disorder that can cause significant cytopenias. Different phenotypes and genotypes have been associated with different clinical courses. LGLL can be associated with numerous other conditions including infections, other malignancies and autoimmune disease. When symptomatic, the mainstay of treatment is immunosuppression. However, time to...

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PMID: 40517544
DOI: 10.1002/hon.70076

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