Article
High-level serum B-cell activating factor and promoter polymorphisms in patients with idiopathic thrombocytopenic purpura.
British journal of haematology - 1 Jan 2007
Emmerich Florian, Bal Gürkan, Barakat Alaa, Milz Julian, Mühle Caroline, Martinez-Gamboa Lorena, Dörner Thomas, Salama Abdulgabar
Abstract excerpt
Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder in which platelets are opsonised by autoantibodies and destroyed by macrophages. Therefore, ITP represents a prototype of a B-cell-mediated autoimmune disorder. B-cell activating factor (BAFF) is a member of the tumour necrosis factor family and an important regulator of B-cell development. BAFF levels were determined in serum samples from 53...
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