Article
Genetic variation in B-cell-activating factor is associated with an increased risk of developing B-cell non-Hodgkin lymphoma.
Cancer research - 15 May 2009
Novak Anne J, Slager Susan L, Fredericksen Zachary S, Wang Alice H, Manske Michelle M, Ziesmer Steven, Liebow Mark, Macon William R, Dillon Stacey R, Witzig Thomas E, Cerhan James R, Ansell Stephen M
Abstract excerpt
Elevated B-cell-activating factor (BAFF; TNFSF13B) levels have been found in patients with B-cell malignancies and autoimmune diseases, suggesting that it may play a pathogenic role. We previously found that a single nucleotide polymorphism (SNP) in the TNFSF13B promoter resulted in increased transcription, suggesting that genetic variation in TNFSF13B may influence its expression. We therefore wanted to...
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