Article
Tumor necrosis factor-α -308G/A gene polymorphism in Egyptian children with immune thrombocytopenic purpura.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Jul 2014
El Sissy Maha H, El Sissy A H, Elanwary Sherif
Abstract excerpt
Immune thrombocytopenic purpura (ITP) is an autoimmune disease characterized by increased platelet destruction. Although the cause of ITP remains unclear, it is accepted that both environmental and genetic factors play an important role in the development of the disease. Children with ITP have a T-helper 1-type cytokine pattern with elevated levels of tumor necrosis factor-alpha (TNF-α) as in most autoimmune...
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