Article
[Association between genetic polymorphisms in folate metabolic enzyme genes and colorectal cancer: a nested case-control study].
Zhonghua zhong liu za zhi [Chinese journal of oncology] - 1 Jun 2006
Chen Kun, Song Liang, Jin Ming-Juan, Fan Chun-Hong, Jiang Qin-Ting, Yu Wei-Ping
Abstract excerpt
OBJECTIVE: To investigate the interrelationship of genetic polymorphisms in folate metabolic enzymes (MTHFRC677T, MTHFRA1298C, MTRA2756G and MTRRA66G) and their combinative effects with colorectal cancer (CRC). METHODS: A nested case-control study was designed and carried out. 140 CRC patients and 343 control subjects were included in this study. Polymorphisms of folate metabolic enzyme genes were genotyped by...
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