Plasmodium falciparum phenotypic and genotypic resistance profile during the emergence of Piperaquine resistance in Northeastern Thailand.

doi:10.1038/s41598-021-92735-6

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Plasmodium falciparum phenotypic and genotypic resistance profile during the emergence of Piperaquine resistance in Northeastern Thailand.

Scientific reports - 28 Jun 2021

Boonyalai Nonlawat, Thamnurak Chatchadaporn, Sai-Ngam Piyaporn, Ta-Aksorn Winita, Arsanok Montri, Uthaimongkol Nichapat, Sundrakes Siratchana, Chattrakarn Sorayut, Chaisatit Chaiyaporn, Praditpol Chantida, Fagnark Watcharintorn, Kirativanich Kirakarn, Chaorattanakawee Suwanna, Vanachayangkul Pattaraporn, Lertsethtakarn Paphavee, Gosi Panita, Utainnam Darunee, Rodkvamtook Wuttikon, Kuntawunginn Worachet, Vesely Brian A, Spring Michele D, Fukuda Mark M, Lanteri Charlotte, Walsh Douglas, Saunders David L, Smith Philip L, Wojnarski Mariusz, Sirisopana Narongrid, Waters Norman C, Jongsakul Krisada, Gaywee Jariyanart

Abstract excerpt

Malaria remains a public health problem in Thailand, especially along its borders where highly mobile populations can contribute to persistent transmission. This study aimed to determine resistant genotypes and phenotypes of 112 Plasmodium falciparum isolates from patients along the Thai-Cambodia border during 2013-2015. The majority of parasites harbored a pfmdr1-Y184F mutation. A single pfmdr1 copy number had...

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PMID: 34183715
DOI: 10.1038/s41598-021-92735-6
PMCID: PMC8238947

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