Article
The patterns of mutation and amplification of Plasmodium falciparum pfcrt and pfmdr1 genes in Thailand during the year 1988 to 2003.
Parasitology research - 1 Aug 2010
Mungthin Mathirut, Suwandittakul Nantana, Chaijaroenkul Wanna, Rungsrihirunrat Kanchana, Harnyuttanakorn Pongchai, Seugorn Aree, Na Bangchang Kesara
Abstract excerpt
The study investigated the patterns of pfmdr1 and pfcrt genetic polymorphisms in Plasmodium falciaprum isolates collected from Thailand during the periods 1988-1993 (35 isolates), and 2003 (21 isolates). Pfcrt polymorphisms were almost universal for the mutations at codons K76T, A220S, Q271E, N326S, and R371I. All parasites displayed the chloroquine (CQ)-resistant phenotypes. This data suggested that pfcrt gene...
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