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Article

Ribosome-catalyzed synthesis of protein/oligopeptides with unnatural backbone.

Nucleic acids symposium series (2004) - 1 Jan 2005

Abe Kenji, Sato Nobuhiko, Kanatani Keiichiro, Sando Shinsuke, Aoyama Yasuhiro

Abstract excerpt

Nonsense suppression method was used to probe the allowable modification of substrate (amino acid) backbone in the prokaryotic ribosomal system. Dihydrofolate reductase (DHFR) with an amber mutation was translated in the RF1-diminished prokaryotic cell free translation system in the presence of chemically-misacylated yeast tRNA(Phe)CUA. The prokaryotic ribosome showed a restricted tolerance to the backbone...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17150739
DOI: 10.1093/nass/49.1.273

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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