Ribosome-mediated polymerization of long chain carbon and cyclic amino acids into peptides in vitro.

Abstract excerpt

Ribosome-mediated polymerization of backbone-extended monomers into polypeptides is challenging due to their poor compatibility with the translation apparatus, which evolved to use α-L-amino acids. Moreover, mechanisms to acylate (or charge) these monomers to transfer RNAs (tRNAs) to make aminoacyl-tRNA substrates is a bottleneck. Here, we rationally design non-canonical amino acid analogs with extended carbon...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Amino Acids, Cyclic
• Share to Genetic Engineering