Rational design of aminoacyl-tRNA synthetase specific for p-acetyl-L-phenylalanine.

doi:10.1016/j.bbrc.2009.11.125

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Article

Rational design of aminoacyl-tRNA synthetase specific for p-acetyl-L-phenylalanine.

Biochemical and biophysical research communications - 1 Jan 2010

Sun Renhua, Zheng Heng, Fang Zhengzhi, Yao Wenbing

Abstract excerpt

The Methanococcus jannaschii tRNA(Tyr)/tyrosyl-tRNA synthetase pair has been engineered to incorporate unnatural amino acids into proteins in Escherichia coli site-specifically. In order to add other unnatural amino acids into proteins by this approach, the amino acid binding site of M. jannaschii tyrosyl-tRNA synthetase need to be mutated. The crystal structures of M. jannaschii tyrosyl-tRNA synthetase and its...

Topics

Crystallography, X-Ray
Escherichia coli
Methanococcus
Mutation
Phenylalanine
Protein Biosynthesis
Protein Conformation
Protein Engineering
Tyrosine
Tyrosine-tRNA Ligase

Source

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Identifiers

PMID: 19944076
DOI: 10.1016/j.bbrc.2009.11.125

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