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Article

High-throughput SNP genotyping by combining exonuclease III, nuclease S1, and acridine-bearing PNA.

Nucleic acids symposium series (2004) - 1 Jan 2004

Ren Binzhi, Komiyama Makoto

Abstract excerpt

Recently we reported a precise and straightforward method for genotyping of single nucleotide polymorphisms (SNPs) in double-stranded DNA substrates. The substrates were consecutively treated by two enzymes (exonuclease III and nuclease S1) in the presence of peptide nucleic acid (PNA) probes, and the resultant DNA fragments were analyzed by mass spectroscopy. Here, the selectivity of DNA scission by nuclease S1...

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Share to Apolipoproteins E
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Peptide Nucleic Acids

Share to Polymorphism, Single Nucleotide

Share to Single-Strand Specific DNA and RNA Endonucleases

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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Identifiers

PMID: 17150539
DOI: 10.1093/nass/48.1.183

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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