Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel approach for SNP genotyping based on site-selective RNA scission.

Nucleic acids research. Supplement (2001) - 1 Jan 2002

Kuzuya Akinori, Mizoguchi Ryo, Morisawa Fumi, Komiyama Makoto

Abstract excerpt

Novel genotyping method for single nucleotide polymorphisms (SNPs), based on site-selective RNA scission, has been developed. A substrate RNA is activated at two sites by complementary acridine-modified DNA having two acridine residues, and is site-selectively cleaved by metal ion catalyst to produce short RNA fragment containing the SNP site. Genotype of the substrate is accurately and easily determined by mass...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Genotype
Share to Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 12903139
DOI: 10.1093/nass/2.1.129

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel approach for SNP genotyping based on site-selective RNA scission.PMID 12903139Read ↗

Site-selective RNA scission at two sites for precise genotyping of SNPs by mass spectrometry.Semantic proximity Read ↗

High-throughput SNP genotyping by combining exonuclease III, nuclease S1, and acridine-bearing PNA.Semantic proximity Read ↗

Novel biosensing methodologies for improving the detection of single nucleotide polymorphism.Semantic proximity Read ↗

Enhanced discrimination of single nucleotide polymorphism in genotyping by phosphorothioate proofreading allele-specific amplification.Semantic proximity Read ↗

Novel strategy for single nucleotide polymorphism (SNP) genotyping by heteroduplex analysis: specific stabilization of TT mismatch base pair by mercury (II) cation and CC mismatch base pair by silver (I) cation.Semantic proximity Read ↗

Multiplex single-nucleotide polymorphism genotyping by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.Semantic proximity Read ↗

Touchdown thermocycling program enables a robust single nucleotide polymorphism typing method based on allele-specific real-time polymerase chain reaction.Semantic proximity Read ↗

Simple and accurate visual detection of single nucleotide polymorphism based on colloidal gold nucleic acid strip biosensor and primer-specific PCR.Semantic proximity Read ↗

SNP genotyping using alkali cleavage of RNA/DNA chimeras and MALDI time-of-flight mass spectrometry.Semantic proximity Read ↗

Efficient mutagenesis method for producing the templates of single nucleotide polymorphisms.Semantic proximity Read ↗

A simple and accurate SNP scoring strategy based on typeIIS restriction endonuclease cleavage and matrix-assisted laser desorption/ionization mass spectrometry.Semantic proximity Read ↗

Single-base extension and ELISA-based approach for single-nucleotide polymorphisms genotyping.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.