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Article

Deleterious genomic mutation rate for viability in Drosophila melanogaster using concomitant sibling controls.

Biology letters - 22 Dec 2005

Gong Yi, Woodruff R C, Thompson J N

Abstract excerpt

New deleterious mutations may reduce health and fitness and are involved in the evolution and maintenance of numerous biological processes. Hence, it is important to estimate the deleterious genomic mutation rate (U) in representative higher organisms. However, these estimated rates vary widely, mainly because of inadequate experimental controls. Here we describe an experimental design (the Binscy assay) with...

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PMID: 17148241
DOI: 10.1098/rsbl.2005.0364
PMCID: PMC1626383

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