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Article

New estimates of the rates and effects of mildly deleterious mutation in Drosophila melanogaster.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jan 1999

Fry J D, Keightley P D, Heinsohn S L, Nuzhdin S V

Abstract excerpt

The genomic rate and distribution of effects of deleterious mutations are important parameters in evolutionary theory. The most detailed information comes from the work of Mukai and Ohnishi, who allowed mutations to accumulate on Drosophila melanogaster second chromosomes, shielded from selection and recombination by being maintained heterozygous in males. Averaged over studies, the estimated rate of nonlethal...

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Identifiers

PMID: 9892675
DOI: 10.1073/pnas.96.2.574
PMCID: PMC15178

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