New estimates of the rates and effects of mildly deleterious mutation in Drosophila melanogaster.

doi:10.1073/pnas.96.2.574

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Article

New estimates of the rates and effects of mildly deleterious mutation in Drosophila melanogaster.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jan 1999

Fry J D, Keightley P D, Heinsohn S L, Nuzhdin S V

Abstract excerpt

The genomic rate and distribution of effects of deleterious mutations are important parameters in evolutionary theory. The most detailed information comes from the work of Mukai and Ohnishi, who allowed mutations to accumulate on Drosophila melanogaster second chromosomes, shielded from selection...

Topics

Analysis of Variance
Animals
Chromosomes
Crosses, Genetic
Drosophila melanogaster
Environment
Genetics, Population
Genotype
Models, Genetic
Mortality
Mutation

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