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Article

Release of autoinhibition converts ESCRT-III components into potent inhibitors of HIV-1 budding.

Proceedings of the National Academy of Sciences of the United States of America - 12 Dec 2006

Zamborlini Alessia, Usami Yoshiko, Radoshitzky Sheli R, Popova Elena, Palu Giorgio, Göttlinger Heinrich

Abstract excerpt

The endosomal sorting complex ESCRT-III, which is formed by the structurally related CHMP proteins, is engaged by HIV-1 to promote viral budding. Here we show that progressive truncations into the C-terminal acidic domains of CHMP proteins trigger an increasingly robust anti-HIV budding activity. Together with biochemical evidence for specific intramolecular interactions between the basic and acidic halves of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17146056
DOI: 10.1073/pnas.0603788103
PMCID: PMC1748189

Genes

CHMP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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