Article
A Consensus View of ESCRT-Mediated Human Immunodeficiency Virus Type 1 Abscission
18 Jul 2017
Abstract excerpt
The strong dependence of retroviruses, such as human immunodeficiency virus type 1 (HIV-1), on host cell factors is no more apparent than when the endosomal sorting complex required for transport (ESCRT) machinery is purposely disengaged. The resulting potent inhibition of retrovirus release underscores the importance of understanding fundamental structure-function relationships at the ESCRT-HIV-1 interface....