Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MARCH8 inhibits viral infection by two different mechanisms.

eLife - 11 Aug 2020

Zhang Yanzhao, Tada Takuya, Ozono Seiya, Kishigami Satoshi, Fujita Hideaki, Tokunaga Kenzo

Abstract excerpt

Membrane-associated RING-CH 8 (MARCH8) inhibits infection with both HIV-1 and vesicular stomatitis virus G-glycoprotein (VSV-G)-pseudotyped viruses by reducing virion incorporation of envelope glycoproteins. The molecular mechanisms by which MARCH8 targets envelope glycoproteins remain unknown. Here, we show two different mechanisms by which MARCH8 inhibits viral infection. Viruses pseudotyped with the VSV-G...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HEK293 Cells
Share to HIV-1
Share to HIV Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Rhabdoviridae Infections

Share to Ubiquitin-Protein Ligases

Share to Viral Envelope Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 32778221
DOI: 10.7554/eLife.57763
PMCID: PMC7419139

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MARCH8 inhibits viral infection by two different mechanisms.PMID 32778221Read ↗

Mechanism of Viral Glycoprotein Targeting by Membrane-Associated RING-CH Proteins.Semantic proximity Read ↗

E3 ubiquitin ligase MARCH5 positively regulates Japanese encephalitis virus infection by catalyzing the K27-linked polyubiquitination of viral E protein and inhibiting MAVS-mediated type I interferon productionSemantic proximity Read ↗

TRIM7 ubiquitinates SARS-CoV-2 membrane protein to limit apoptosis and viral replication.Semantic proximity Read ↗

TRIM7 ubiquitinates SARS-CoV-2 membrane protein to limit apoptosis and viral replicationSemantic proximity Read ↗

MARCH6 suppresses Tembusu virus replication by targeting viral NS5 protein for TOLLIP-mediated selective autophagic degradationSemantic proximity Read ↗

Pseudorabies virus tegument protein UL13 recruits RNF5 to inhibit STING-mediated antiviral immunitySemantic proximity Read ↗

Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5.Semantic proximity Read ↗

The Kaposi's sarcoma-associated herpesvirus K5 E3 ubiquitin ligase modulates targets by multiple molecular mechanisms.Semantic proximity Read ↗

E3-14.7K is recruited to TNF-receptor 1 and blocks TNF cytolysis independent from interaction with optineurin.Semantic proximity Read ↗

Role of TRIM5α RING Domain E3 Ubiquitin Ligase Activity in Capsid Disassembly, Reverse Transcription Blockade, and Restriction of Simian Immunodeficiency VirusSemantic proximity Read ↗

ISG15 Is Required for the Dissemination of Vaccinia Virus Extracellular VirionsSemantic proximity Read ↗

Natural mutations in IFITM3 modulate post-translational regulation and toggle antiviral specificity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.