Article

RetroCHMP3 Blocks Budding of Enveloped Viruses Without Blocking Cytokinesis

2020-08-31

Abstract excerpt

<h4>Summary</h4> Many enveloped viruses require the endosomal sorting complexes required for transport (ESCRT) pathway to exit infected cells. This highly conserved pathway mediates essential cellular membrane fission events, which restricts the acquisition of adaptive mutations to counteract viral co-option. Here, we describe duplicated and truncated copies of the ESCRT-III factor CHMP3 that block ESCRT-dependen...

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Literature Corpus work: 7ebd8cc3-1087-51bf-8081-d51fa403343d
DOI: 10.1101/2020.08.30.273656

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