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Article

ALIX-CHMP4 interactions in the human ESCRT pathway.

Proceedings of the National Academy of Sciences of the United States of America - 3 Jun 2008

McCullough John, Fisher Robert D, Whitby Frank G, Sundquist Wesley I, Hill Christopher P

Abstract excerpt

The ESCRT pathway facilitates membrane fission events during enveloped virus budding, multivesicular body formation, and cytokinesis. To promote HIV budding and cytokinesis, the ALIX protein must bind and recruit CHMP4 subunits of the ESCRT-III complex, which in turn participate in essential membrane remodeling functions. Here, we report that the Bro1 domain of ALIX binds specifically to C-terminal residues of...

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Identifiers

PMID: 18511562
DOI: 10.1073/pnas.0801567105
PMCID: PMC2409388

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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