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Article

SCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling.

Molecular biology of the cell - 1 Mar 2009

Aoh Quyen L, Castle Anna M, Hubbard Charles H, Katsumata Osamu, Castle J David

Abstract excerpt

The epidermal growth factor receptor (EGFR) is targeted for lysosomal degradation by ubiquitin-mediated interactions with the ESCRTs (endosomal-sorting complexes required for transport) in multivesicular bodies (MVBs). We show that secretory carrier membrane protein, SCAMP3, localizes in part to early endosomes and negatively regulates EGFR degradation through processes that involve its ubiquitylation and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19158374
DOI: 10.1091/mbc.e08-09-0894
PMCID: PMC2655259

Genes

SCAMP3
EGFR
PSAP
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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