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Article

The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain.

Molecular and cellular biology - 1 Jan 2003

Durst Kristie L, Lutterbach Bart, Kummalue Tanawan, Friedman Alan D, Hiebert Scott W

Abstract excerpt

Inversion(16) is one of the most frequent chromosomal translocations found in acute myeloid leukemia (AML), occurring in over 8% of AML cases. This translocation results in a protein product that fuses the first 165 amino acids of core binding factor beta to the coiled-coil region of a smooth muscle myosin heavy chain (CBFbeta/SMMHC). CBFbeta interacts with AML1 to form a heterodimer that binds DNA; this...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12509458
DOI: 10.1128/MCB.23.2.607-619.2003
PMCID: PMC151524

Genes

HDAC8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain.PMID 12509458Read ↗

The inv(16) cooperates with ARF haploinsufficiency to induce acute myeloid leukemia.Semantic proximity Read ↗

Acute myeloid leukemia with Inv (16) produces a chimeric transcription factor with a myosin heavy chain tail.Semantic proximity Read ↗

Pathogenesis of acute myeloid leukaemia and inv(16)(p13;q22): a paradigm for understanding leukaemogenesis?Semantic proximity Read ↗

Fusion Between Transcription Factor CBFβ/PEBP2β and a Myosin Heavy Chain in Acute Myeloid LeukemiaSemantic proximity Read ↗

CBFB-SMMHC is correlated with increased calreticulin expression and suppresses the granulocytic differentiation factor CEBPA in AML with inv(16)Semantic proximity Read ↗

Cbfbeta reduces Cbfbeta-SMMHC-associated acute myeloid leukemia in mice.Semantic proximity Read ↗

The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates.Semantic proximity Read ↗

FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia.Semantic proximity Read ↗

Core-Binding Factor Acute Myeloid LeukemiaSemantic proximity Read ↗

Overexpression of core-binding factor alpha (CBF alpha) reverses cellular transformation by the CBF beta-smooth muscle myosin heavy chain chimeric oncoprotein.Semantic proximity Read ↗

[Driver Mutations in Acute Myeloid Leukemia with Inversion of Chromosome 16].Semantic proximity Read ↗

Tissue Specific Requirement for the Inv(16) Oncogene <i>CBFB::MYH11</i> in Acute Myeloid LeukemiaSemantic proximity Read ↗

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