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Article

Overexpression of core-binding factor alpha (CBF alpha) reverses cellular transformation by the CBF beta-smooth muscle myosin heavy chain chimeric oncoprotein.

Molecular and cellular biology - 1 Sept 1995

Hajra A, Liu P P, Speck N A, Collins F S

Abstract excerpt

A fusion between the transcription factor core-binding factor beta (CBF beta; also known as PEBP2 beta) and the tail region of smooth muscle myosin heavy chain (SMMHC) is generated by an inversion of chromosome 16 [inv(16) (p13q22)] associated with the M4Eo subtype of acute myeloid leukemia. We have previously shown that this CBF beta-SMMHC chimeric protein can transform NIH 3T3 cells and that this process...

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Identifiers

PMID: 7651416
DOI: 10.1128/MCB.15.9.4980
PMCID: PMC230745

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Overexpression of core-binding factor alpha (CBF alpha) reverses cellular transformation by the CBF beta-smooth muscle myosin heavy chain chimeric oncoprotein.PMID 7651416Read ↗

The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates.Semantic proximity Read ↗

Cbfbeta reduces Cbfbeta-SMMHC-associated acute myeloid leukemia in mice.Semantic proximity Read ↗

The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain.Semantic proximity Read ↗

Fusion Between Transcription Factor CBFβ/PEBP2β and a Myosin Heavy Chain in Acute Myeloid LeukemiaSemantic proximity Read ↗

Acute myeloid leukemia with Inv (16) produces a chimeric transcription factor with a myosin heavy chain tail.Semantic proximity Read ↗

CBFB-SMMHC is correlated with increased calreticulin expression and suppresses the granulocytic differentiation factor CEBPA in AML with inv(16)Semantic proximity Read ↗

The inv(16) cooperates with ARF haploinsufficiency to induce acute myeloid leukemia.Semantic proximity Read ↗

Identification of a region on the outer surface of the CBFbeta-SMMHC myeloid oncoprotein assembly competence domain critical for multimerization.Semantic proximity Read ↗

FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia.Semantic proximity Read ↗

Identification of the chimeric protein product of the <i>CBFB‐MYH11</i> fusion gene in inv(16) leukemia cellsSemantic proximity Read ↗

Recovery of mitogenic activity of a growth factor mutant with a nuclear translocation sequence.Semantic proximity Read ↗

Molecular cloning and functional analysis of the promoter region of rat nonmuscle myosin heavy chain-B gene.Semantic proximity Read ↗

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