Overexpression of core-binding factor alpha (CBF alpha) reverses cellular transformation by the CBF beta-smooth muscle myosin heavy chain chimeric oncoprotein.

doi:10.1128/MCB.15.9.4980

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Overexpression of core-binding factor alpha (CBF alpha) reverses cellular transformation by the CBF beta-smooth muscle myosin heavy chain chimeric oncoprotein.

Molecular and cellular biology - 1 Sept 1995

Hajra A, Liu P P, Speck N A, Collins F S

Abstract excerpt

A fusion between the transcription factor core-binding factor beta (CBF beta; also known as PEBP2 beta) and the tail region of smooth muscle myosin heavy chain (SMMHC) is generated by an inversion of chromosome 16 [inv(16) (p13q22)] associated with the M4Eo subtype of acute myeloid leukemia. We have previously shown that this CBF beta-SMMHC chimeric protein can transform NIH 3T3 cells and that this process...

Topics

3T3 Cells
Animals
Base Sequence
Cell Transformation, Neoplastic
Chromosome Inversion
Chromosomes, Human, Pair 16
Core Binding Factor Alpha 2 Subunit
Core Binding Factor alpha Subunits
Core Binding Factor beta Subunit
DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation, Neoplastic

Humans

Leukemia, Myeloid

Mice

Models, Biological

Molecular Sequence Data

Mutation

Neoplasm Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 7651416
DOI: 10.1128/MCB.15.9.4980
PMCID: PMC230745

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7651416-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of core-binding factor alpha (CBF alpha) reverses cellular transformation by the CBF beta-smooth muscle myosin heavy chain chimeric oncoprotein.PMID 7651416Read ↗

The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates.Semantic proximity Read ↗

Cbfbeta reduces Cbfbeta-SMMHC-associated acute myeloid leukemia in mice.Semantic proximity Read ↗

The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain.Semantic proximity Read ↗

Fusion Between Transcription Factor CBFβ/PEBP2β and a Myosin Heavy Chain in Acute Myeloid LeukemiaSemantic proximity Read ↗

Acute myeloid leukemia with Inv (16) produces a chimeric transcription factor with a myosin heavy chain tail.Semantic proximity Read ↗

CBFB-SMMHC is correlated with increased calreticulin expression and suppresses the granulocytic differentiation factor CEBPA in AML with inv(16)Semantic proximity Read ↗

The inv(16) cooperates with ARF haploinsufficiency to induce acute myeloid leukemia.Semantic proximity Read ↗

Identification of a region on the outer surface of the CBFbeta-SMMHC myeloid oncoprotein assembly competence domain critical for multimerization.Semantic proximity Read ↗

FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia.Semantic proximity Read ↗

Identification of the chimeric protein product of the <i>CBFB‐MYH11</i> fusion gene in inv(16) leukemia cellsSemantic proximity Read ↗

Recovery of mitogenic activity of a growth factor mutant with a nuclear translocation sequence.Semantic proximity Read ↗

Molecular cloning and functional analysis of the promoter region of rat nonmuscle myosin heavy chain-B gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.