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Article

The core-binding factor leukemias: lessons learned from murine models.

Current opinion in genetics & development - 1 Feb 2003

Downing James R

Abstract excerpt

The recent development of murine models of core-binding factor leukemias has provided important insights into the underlying molecular pathology of this common subtype of acute myeloid leukemia. Evidence from these models supports the idea that acute myeloid leukemia 1/core-binding factor beta-subunit (AML1/CBFbeta) has a critical role in the control of the self-renewal capacity of hematopoietic stem cells and...

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Identifiers

PMID: 12573435
DOI: 10.1016/s0959-437x(02)00018-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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