Article
The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates.
Molecular and cellular biology - 1 Dec 1998
Adya N, Stacy T, Speck N A, Liu P P
Abstract excerpt
The fusion gene CBFB-MYH11 is generated by the chromosome 16 inversion associated with acute myeloid leukemias. This gene encodes a chimeric protein involving the core binding factor beta (CBFbeta) and the smooth-muscle myosin heavy chain (SMMHC). Mouse model studies suggest that this chimeric pr...
Topics
- 3T3 Cells
- Actins
- Animals
- Cell Nucleus
- Chromosomes, Human, Pair 16
- Core Binding Factor Alpha 1 Subunit
- Core Binding Factor Alpha 2 Subunit
- Core Binding Factor beta Subunit
- Core Binding Factors
- DNA-Binding Proteins
- Fluorescent Antibody Technique
- Gene Deletion
- Humans
- Mice