Article
beta-2-adrenergic receptor gene polymorphism confers susceptibility to Graves disease.
International journal of molecular medicine - 1 Jan 2007
Jazdzewski Krystian, Bednarczuk Tomasz, Stepnowska Magdalena, Liyanarachchi Sandya, Suchecka-Rachon Krystyna, Limon Janusz, Narkiewicz Krzysztof
Abstract excerpt
Graves disease (GD) is an autoimmune disorder with genetic predisposition. The polymorphisms 47A-->G (Arg16Gly) and 79C-->G (Gln27Glu) of the adrenergic beta-2 receptor (ADRB2) gene in the 5q32 region affect the functional reaction to adrenergic stimulation, which contributes to the regulation of immunological response. The -367T-->C polymorphism within the 5'-leading regulatory sequence affects ADRB2...
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