Article
Association study between methylenetetrahydrofolate reductase gene polymorphisms and Graves' disease.
Cell biochemistry and function - 1 Oct 2010
Mao Renfang, Fan Yihui, Zuo Lulu, Geng Dongfeng, Meng Fantao, Zhu Jing, Li Qiang, Qiao Hong, Jin Yan, Bai Jing, Fu Songbin
Abstract excerpt
5,10-Methylenetetrahydrofolate reductase (MTHFR) catalyzes the metabolism of folate and nucleotides, which are essential for DNA synthesis and methylation. It is highly polymorphic, and its variant genotypes result in lower enzymatic activity and higher plasma homocysteine. Previous studies have...
Topics
- Adolescent
- Adult
- Aged
- Case-Control Studies
- Child
- China
- Female
- Genetic Association Studies
- Graves Disease
- Haplotypes
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Polymerase Chain Reaction