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Article

The functional variant of the CLC-Kb channel T481S is not associated with blood pressure or hypertension in Swedes.

Journal of hypertension - 1 Jan 2007

Fava Cristiano, Montagnana Martina, Almgren Peter, Rosberg Lena, Guidi Gian Cesare, Berglund Göran, Melander Olle

Abstract excerpt

OBJECTIVE: A common threonine481serine polymorphism (T481S) has been shown in vitro to strongly activate the chloride channel Kb (CLC-Kb) expressed in the kidney, and the 481S allele has been associated with human hypertension. The study aim was to evaluate the association of the T481S polymorphism with blood pressure (BP) levels and the BP progression rate in Swedes. DESIGN AND METHODS: The cardiovascular cohort...

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Identifiers

PMID: 17143181
DOI: 10.1097/HJH.0b013e3280103a5a

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CLC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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