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Article

CLCNKB-T481S and essential hypertension in a Ghanaian population.

Journal of hypertension - 1 Feb 2009

Sile Saba, Velez Digna R, Gillani Niloufar B, Narsia Tinatin, Moore Jason H, George Alfred L, Vanoye Carlos G, Williams Scott M

Abstract excerpt

OBJECTIVE: Prior to the discovery of chloride channel Kb with a variant threonine change to serine at position 481 (CLCNKB-T481S) there were no variants or clinical disorders associated with gain-of-function defects in thick ascending limb of the kidney channels or transporters. CLCNKB-T481S is a novel gain-of-function variant that has been associated with essential hypertension. This finding has not been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19226700
DOI: 10.1097/hjh.0b013e3283140c9e
PMCID: PMC3845205

Genes

CLCNKB

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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