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Article

Contribution of SLC7A1 genetic variant to hypertension, the TAMRISK study.

BMC medical genetics - 10 Jul 2013

Määttä Kirsi, Kunnas Tarja, Nikkari Seppo T

Abstract excerpt

BACKGROUND: The rs41318021 polymorphism in the SLC7A1 gene affects endothelial NO production through changes in L-arginine transport. This variation could thus hypothetically cause dysfunction of endothelium and lead to hypertension. The association of rs41318021 with hypertension was therefore studied in a Finnish cohort. METHODS: A total of 412 hypertensive cases and 771 non-hypertensive controls from a Finnish...

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PMID: 23841815
DOI: 10.1186/1471-2350-14-69
PMCID: PMC3710090

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