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Article

Common genetic variants and haplotypes in renal CLCNKA gene are associated to salt-sensitive hypertension.

Human molecular genetics - 1 Jul 2007

Barlassina Cristina, Dal Fiume Chiara, Lanzani Chiara, Manunta Paolo, Guffanti Guia, Ruello Antonella, Bianchi Giuseppe, Del Vecchio Lucia, Macciardi Fabio, Cusi Daniele

Abstract excerpt

Abnormal renal reabsorption of sodium (Na(+)) is likely to play a role in the pathogenesis of salt-sensitivity. In the kidney, chloride channels CLC-Ka (gene CLCNKA) and CLC-Kb (gene CLCNKB) and their subunit Barttin (gene BSND) have important effects on the control of Na(+) and water homeostasis...

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Source

Identifiers

PMID: 17510212
DOI: 10.1093/hmg/ddm112

Genes

CLCNKA
BSND
CLCNKB
CLC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17510212-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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