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Article

STK39 and WNK1 Are Potential Hypertension Susceptibility Genes in the BELHYPGEN Cohort.

Medicine - 1 Apr 2016

Persu Alexandre, Evenepoel Lucie, Jin Yu, Mendola Antonella, Ngueta Gérard, Yang Wen-Yi, Gruson Damien, Horman Sandrine, Staessen Jan A, Vikkula Miikka

Abstract excerpt

The serine/threonine kinase With-No-Lysine (K) Kinase 1 (WNK1) activates the thiazide-sensitive Na(+)/Cl(-) cotransporter through phosphorylation of STE20/SPS1-related proline/alanine-rich kinase, another serine/threonine kinase encoded by STK39. The aim of this study was to look for association between WNK1 and STK39 gene variants, and blood pressure (BP) and hypertension. Seven hundred seventy-nine Caucasian...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 27082544
DOI: 10.1097/MD.0000000000002968
PMCID: PMC4839787

Genes

STK39
WNK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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