Analysis of the interaction between the bacterial superantigen streptococcal pyrogenic exotoxin A (SpeA) and the human T-cell receptor.

doi:10.1046/j.1365-2958.1997.3381696.x

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Article

Analysis of the interaction between the bacterial superantigen streptococcal pyrogenic exotoxin A (SpeA) and the human T-cell receptor.

Molecular microbiology - 1 Apr 1997

Kline J B, Collins C M

Abstract excerpt

Streptococcus pyogenes that produces the bacterial superantigen streptococcal pyrogenic exotoxin A (SpeA) is associated with outbreaks of streptococcal toxic shock syndrome (STSS) in the United States and Europe. SpeA stimulates V beta 2.1, 12.2, 14.1, and 15.1-positive T cells, and the lymphokin...

Topics

Alleles
Amino Acid Sequence
Bacterial Proteins
Binding Sites
Exotoxins
Humans
Membrane Proteins
Molecular Sequence Data
Mutation
Peptides
Receptors, Antigen, T-Cell, alpha-beta
Streptococcus pyogenes
Superantigens
T-Lymphocytes

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