Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human Vγ9Vδ2 T cells.

Immunity - 17 Apr 2014

Sandstrom Andrew, Peigné Cassie-Marie, Léger Alexandra, Crooks James E, Konczak Fabienne, Gesnel Marie-Claude, Breathnach Richard, Bonneville Marc, Scotet Emmanuel, Adams Erin J

Abstract excerpt

In humans, Vγ9Vδ2 T cells detect tumor cells and microbial infections, including Mycobacterium tuberculosis, through recognition of small pyrophosphate containing organic molecules known as phosphoantigens (pAgs). Key to pAg-mediated activation of Vγ9Vδ2 T cells is the butyrophilin 3A1 (BTN3A1) protein that contains an intracellular B30.2 domain critical to pAg reactivity. Here, we have demonstrated through...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens
Share to Butyrophilins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diphosphonates

Share to Imidazoles

Share to Intracellular Space

Share to Lymphocyte Activation

Share to Protein Engineering

Share to Receptors, Antigen, T-Cell, gamma-delta

Source

Open in PubMed Open full text

Identifiers

PMID: 24703779
DOI: 10.1016/j.immuni.2014.03.003
PMCID: PMC4028361

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human Vγ9Vδ2 T cells.PMID 24703779Read ↗

A distinct topology of BTN3A IgV and B30.2 domains controlled by juxtamembrane regions favors optimal human γδ T cell phosphoantigen sensingSemantic proximity Read ↗

BTN3A1 Discriminates γδ T Cell Phosphoantigens from Nonantigenic Small Molecules via a Conformational Sensor in Its B30.2 Domain.Semantic proximity Read ↗

Butyrophilin-2A1 Directly Binds Germline-Encoded Regions of the Vγ9Vδ2 TCR and Is Essential for Phosphoantigen SensingSemantic proximity Read ↗

Phosphoantigens are Molecular Glues that Promote Butyrophilin 3A1/2A1 Association Leading to Vγ9Vδ2 T Cell ActivationSemantic proximity Read ↗

Phosphoantigen sensing combines TCR-dependent recognition of the BTN3A IgV domain and germline interaction with BTN2A1Semantic proximity Read ↗

RhoB Mediates Phosphoantigen Recognition by Vγ9Vδ2 T Cell Receptor.Semantic proximity Read ↗

Mutations to the BTN2A1 Linker Region Impact Its Homodimerization and Its Cytoplasmic Interaction with Phospho-Antigen-Bound BTN3A1.Semantic proximity Read ↗

Functional Phenotypes of Human Vγ9Vδ2 T Cells in Lymphoid Stress Surveillance.Semantic proximity Read ↗

Molecular basis of TCR selectivity, cross-reactivity, and allelic discrimination by a bacterial superantigen: integrative functional and energetic mapping of the SpeC-Vbeta2.1 molecular interface.Semantic proximity Read ↗

Vγ9+Vδ2+Tcell-mediated purging of <i>Listeria monocytogenes</i> -infected epithelial cells requires butyrophilin 3A genesSemantic proximity Read ↗

Human Antibodies Targeting a Transporter Mediate Protection Against TuberculosisSemantic proximity Read ↗

Butyrophilin 2A2 promotes T cell immunoregulation by enhancing CD45 phosphatase activity within the immune synapseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.