Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The superantigens SpeC and TSST-1 specifically activate TRBV12-3/12-4+ memory T cells

20 Jan 2023

Abstract excerpt

Abstract Severe bacterial or viral infections can induce a state of immune hyperactivation that can culminate in a potentially lethal cytokine storm. The classic example is toxic shock syndrome, a life-threatening complication of Staphylococcus aureus or Streptococcus pyogenes infection, which is driven by potent toxins known as superantigens (SAgs). SAgs are thought to promote immune evasion via the promiscuous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36670205
DOI: 10.1038/s42003-023-04420-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The superantigens SpeC and TSST-1 specifically activate TRBV12-3/12-4+ memory T cellsPMID 36670205Read ↗

Toxic Shock Syndrome and Bacterial Superantigens: An UpdateSemantic proximity Read ↗

Staphylococcal Superantigens: Pyrogenic Toxins Induce Toxic ShockSemantic proximity Read ↗

Update on Staphylococcal Superantigen-Induced Signaling Pathways and Therapeutic InterventionsSemantic proximity Read ↗

Analysis of superantigenic toxin Vβ T-cell signatures produced during cases of staphylococcal toxic shock syndrome and septic shockSemantic proximity Read ↗

Manipulation of Innate and Adaptive Immunity by Staphylococcal SuperantigensSemantic proximity Read ↗

Bacterial pyrogenic exotoxins as superantigensSemantic proximity Read ↗

Streptococcal superantigen SpeC induces IL-8 secretion in human epithelial cellsSemantic proximity Read ↗

Staphylococcus aureus isolates encode variant staphylococcal enterotoxin B proteins that are diverse in superantigenicity and lethality.Semantic proximity Read ↗

The TCR Vbeta signature of bacterial superantigens spreads with stimulus strength.Semantic proximity Read ↗

Induction of Immunosuppressive CD8+CD25+FOXP3+ Regulatory T Cells by Suboptimal Stimulation with Staphylococcal Enterotoxin C1.Semantic proximity Read ↗

So many ways of getting in the way: diversity in the molecular architecture of superantigen-dependent T-cell signaling complexes.Semantic proximity Read ↗

Analysis of the interaction between the bacterial superantigen streptococcal pyrogenic exotoxin A (SpeA) and the human T-cell receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.