Article

Streptococcal superantigen SpeC induces IL-8 secretion in human epithelial cells

2026-05-18

Abstract excerpt

Streptococcal pyrogenic exotoxin C (SpeC) is a prototypical superantigen produced by group A Streptococcus . It potently activates a broad subset of T lymphocytes via a bridging interaction involving TCRβ−SpeC−MHC-II. Our recent work demonstrated that SpeC induced profound release of IL-8 from human pharyngeal epithelial cells and this effect was reversible through a specific point mutation in SpeC. This study sy...

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Literature Corpus work: 422f8f04-5d0a-5106-99d7-748b0f3b20fb
DOI: 10.64898/2026.05.18.725648

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