Article
Absence of the wild-type allele (192 base pairs) of a polymorphism in the promoter region of the IGF-I gene but not a polymorphism in the insulin gene variable number of tandem repeat locus is associated with accelerated weight gain in infancy.
Pediatrics - 1 Dec 2006
Landmann Eva, Geller Frank, Schilling Jutta, Rudloff Silvia, Foeller-Gaudier Eleonore, Gortner Ludwig
Abstract excerpt
OBJECTIVE: Our goal was to investigate whether a polymorphism in the insulin-like growth factor I promoter gene (IGF-I, wild-type, 192 base pairs) and in the insulin gene (INS) variable number of tandem repeat locus influence birth weight and weight gain in infancy. PATIENTS AND METHODS: We obtained genomic DNA from 768 children. Exclusion criteria were multiple births, gestational diabetes, maternal diabetes,...
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