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Genetic variation in the type 2 insulin-like growth factor receptor gene and disparity in childhood height.

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society - 1 Dec 2005

Petry Clive J, Ong Ken K, Wingate Dianne L, Brown James, Scott Carolyn D, Jones E Yvonne, Pembrey Marcus E, Dunger David B

Abstract excerpt

OBJECTIVE: The type 2 insulin-like growth factor receptor (IGF2R) is thought to regulate insulin-like growth factor-II (IGF-II) bioavailability by degrading it in the lysosomes after uptake. We hypothesised that polymorphisms in the IGF2R gene could alter size at birth and childhood growth. DESIGN AND METHODS: The hypothesis was tested in a normal birth cohort (Avon Longitudinal Study of Parents and Children) by...

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Body Height
Cohort Studies
Homozygote
Infant, Newborn
Insulin-Like Growth Factor II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Restriction Fragment Length

Receptor, IGF Type 2

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PMID: 16172012
DOI: 10.1016/j.ghir.2005.07.003

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